Listed below are some drugs that may cause hyponatraemia (serum sodium concentration below 135 mmol/L)
- Angiotensin-converting enzyme inhibitors (ACE inhibitors) e.g. ramipril, enalapril
- Angiotensin II receptor blockers e.g. losartan, olmesartan
- Diuretics
- Thiazide and related diuretics e.g. bendroflumethiazide, hydrochlorothiazide, chlortalidone, metolazone, indapamide
- Loop diuretics e.g. bumetanide, furosemide, torasemide
- Potassium-sparing diuretics e.g. amiloride
- Mineralocorticoid receptor antagonists e.g. spironolactone, eplerenone, finerenone
- Heparin
- Antidepressants
- Tricyclic antidepressants e.g. amitriptyline, imipramine, dosulepin
- Selective serotonin reuptake inhibitors (SSRIs) e.g. sertraline, fluoxetine, paroxetine, citalopram
- Monoamine-oxidase inhibitors (MAOIs) e.g. phenelzine, moclobemide
- Antipsychotics
- Phenothiazine e.g. chlorpromazine, thioridazine
- Butyrophenones e.g. haloperidol
- Atypical antipsychotics such as quetiapine, lurasidone, aripiprazole
- Antiepileptics e.g. carbamazepine, sodium valproate, lamotrigine, oxcarbazepine, eslicarbazepine
- Sulphonylureas e.g. chlorpropamide, tolbutamide
- Opioids e.g. morphine
- Atovaquone
- Amphotericin
- Linezolid
- Desmopressin
- Cyclophosphamide
- Acetazolamide
- MDMA (ecstasy)
- Avelumab