Drug Induced Diarrhoea

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Listed below are some drugs that may cause diarrhoea

  • Magnesium containing antacids
  • H2-receptor antagonists e.g. cimetidine, ranitidine
  • Proton pump inhibitors e.g. lansoprazole, omeprazole
  • Granisetron
  • Palonosetron
  • Misoprostol
  • Aminosalicylates: mesalazine, olsalazine, sulfasalazine, balsalazide
  • Orlistat
  • Digoxin
  • Beta-blockers e.g. propranolol, carvedilol
  • Methyldopa
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors) e.g. lisinopril, ramipril
  • Aliskiren
  • Eplerenone
  • Selective serotonin re-uptake inhibitors (SSRIs) e.g. citalopram, fluoxetine
  • Antiretrovirals e.g. abacavir, atazanavir, ritonavir
  • Antifungals e.g. fluconazole, voriconazole, caspofungin, terbinafine
  • Sulfonylureas e.g. gliclazide, glipizide
  • Metformin
  • Acarbose
  • Levothyroxine (usually at excessive dose)
  • Cytotoxic drugs e.g. methotrexate, mercaptopurine
  • Iron preparations e.g. ferrous gluconate, ferrous sulphate
  • Non-steroidal anti-inflammatory drugs (NSAIDs) e.g. indometacin, mefenamic acid, naproxen
  • Bisphosphonates e.g. risendronate, alendronic acid
  • Colchicine
  • Immunosuppressants e.g. leflunomide, mycophenolate mofetil
  • Phosphate
  • Levodopa
  • Acamprosate
  • Vitamin D and analogues e.g. colecalciferol, alfacalcidol, ergocalciferol
  • Acetylcholinesterase inhibitors: rivastigmine, galantamine, donepezil
  • Antibiotics e.g.
    • Penicillins e.g. ampicillin, amoxicillin, benzylpenicillin, phenoxymethylpenicillin, flucloxacillin
    • Cephalosporins e.g. cefalexin, cefaclor, cefotaxime, ceftriaxone
    • Quinolones e.g. ciprofloxacin
    • Tetracyclines e.g. tetracycline, doxycycline
    • Macrolides e.g. erythromycin, clarithromycin
    • Clindamycin

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